User profiles for Arnim Pause
 | Arnim Pause, M.Sc., Ph.D.Professor, Department of Biochemistry, Goodman Cencer Research Centre, McGill�… Verified email at mcgill.ca Cited by 30868 |
[HTML][HTML] mTOR pathways in cancer and autophagy
TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status, …
central regulator of cell growth, proliferation and survival in response to nutritional status, …
[HTML][HTML] Hepatitis C therapeutics: current status and emerging strategies
Chronic infection with hepatitis C virus (HCV) is an emerging global epidemic. The development
of effective HCV antiviral therapeutics continues to be a daunting challenge owing to …
of effective HCV antiviral therapeutics continues to be a daunting challenge owing to …
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
The cloning is described of two related human complementary DNAs encoding polypeptides
that interact specifically with the translation initiation factor elF-4E, which binds to the …
that interact specifically with the translation initiation factor elF-4E, which binds to the …
The ever-evolving role of mTOR in translation
Control of translation allows for the production of stoichiometric levels of each protein in the
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins
Eukaryotic translation initiation factor 4E (eIF-4E), which possesses cap-binding activity,
functions in the recruitment of mRNA to polysomes as part of a three-subunit complex, eIF-4F (…
functions in the recruitment of mRNA to polysomes as part of a three-subunit complex, eIF-4F (…
An oxygen-regulated switch in the protein synthesis machinery
Protein synthesis involves the translation of ribonucleic acid information into proteins, the
building blocks of life. The initial step of protein synthesis is the binding of the eukaryotic …
building blocks of life. The initial step of protein synthesis is the binding of the eukaryotic …
[HTML][HTML] mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
mRNA translation is thought to be the most energy-consuming process in the cell. Translation
and energy metabolism are dysregulated in a variety of diseases including cancer, …
and energy metabolism are dysregulated in a variety of diseases including cancer, …
Inhibition of transcription elongation by the VHL tumor suppressor protein
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose
individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central …
individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central …
PHAS-I as a link between mitogen-activated protein kinase and translation initiation
PHAS-I is a heat-stable protein (relative molecular mass ≈ 12,400) found in many tissues. It
is rapidly phosphorylated in rat adipocytes incubated with insulin or growth factors. …
is rapidly phosphorylated in rat adipocytes incubated with insulin or growth factors. …
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
A Pause, S Lee, RA Worrell…�- Proceedings of the�…, 1997 - National Acad Sciences
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL
syndrome and is an early genetic event associated with sporadic renal cell carcinoma and …
syndrome and is an early genetic event associated with sporadic renal cell carcinoma and …