Rationale: Long-term outcomes after acute kidney injury (AKI) are poorly described. Objectives:
We hypothesized that one single episode of minimal (stage 1) AKI is associated with …

Background. The early detection of circulatory failure in patients with sepsis is important for
successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is …

Early administration of antibiotics is associated with better survival in sepsis, thus screening
and early detection for sepsis is of clinical importance. Current risk stratification scores used …

Objectives: Early identification of patients with infection and at risk of developing severe
disease with organ dysfunction remains a difficult challenge. We aimed to evaluate and validate …

Introduction Rapid detection of, and optimized treatment for, severe sepsis and septic shock
is crucial for successful outcome. Heparin-binding protein (HBP), a potent inducer of …

Objectives: Long-term (1-to 10-year) outcomes after severe sepsis in previously healthy
persons are unknown. We aimed to determine the 1-to 10-year mortality rates of previously …

Neutrophils are crucial mediators of host defense that are recruited to the central nervous
system (CNS) in large numbers during acute bacterial meningitis caused by Streptococcus …

Background Sepsis involves aberrant immune responses to infection, but the exact nature
of this immune dysfunction remains poorly defined. Bacterial endotoxins like …

Background Although sepsis is a major health problem, data on sepsis epidemiology are
scarce. The aim of this study was to assess the incidence of sepsis, based on clinical findings …

The incorporation of machine learning methods into proteomics workflows improves the
identification of disease-relevant biomarkers and biological pathways. However, machine …