Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This variation�…

Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference�…

Phenotypic variation is ubiquitous in biology and is often traceable to underlying genetic and
environmental variation. However, even genetically identical cells in identical environments�…

Stochastic mechanisms are ubiquitous in biological systems. Biochemical reactions that
involve small numbers of molecules are intrinsically noisy, being dominated by large�…

We recently showed that the mammalian genome encodes> 1,000 large intergenic
noncoding (linc) RNAs that are clearly conserved across mammals and, thus, functional�…

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are�…

In Rspondin-based 3D cultures, Lgr5 stem cells from multiple organs form ever-expanding
epithelial organoids that retain their tissue identity. We report the establishment of tumor�…

MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress
gene expression in a sequence-dependent manner. We performed single-cell�…

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the�…

MicroRNAs (miRNAs) are regulatory molecules that participate in diverse biological
processes in animals and plants. While thousands of mammalian genes are potentially�…