[HTML][HTML] Nanog is the gateway to the pluripotent ground state
Pluripotency is generated naturally during mammalian development through formation of the
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell�…
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell�…
[HTML][HTML] JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency
Induced pluripotency depends on cooperativity between expression of defined factors and
the culture environment. The latter also determines the pluripotent cell state, that is, na�ve or�…
the culture environment. The latter also determines the pluripotent cell state, that is, na�ve or�…
[HTML][HTML] Stat3 activation is limiting for reprogramming to ground state pluripotency
J Yang, AL Van Oosten, TW Theunissen, G Guo…�- Cell stem cell, 2010 - cell.com
The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and
induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3�…
induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3�…
[HTML][HTML] Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions
TW Theunissen, AL Van Oosten, G Castelo-Branco…�- Current Biology, 2011 - cell.com
Induced pluripotency requires the expression of defined factors and culture conditions that
support the self-renewal of embryonic stem (ES) cells [1]. Small molecule inhibition of MAP�…
support the self-renewal of embryonic stem (ES) cells [1]. Small molecule inhibition of MAP�…
Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain
Pluripotency is a developmental ground state that can be recreated by direct
reprogramming. Establishment of pluripotency is crucially dependent on the homeodomain�…
reprogramming. Establishment of pluripotency is crucially dependent on the homeodomain�…
[HTML][HTML] NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program
HT Stuart, AL Van Oosten, A Radzisheuskaya…�- Current Biology, 2014 - cell.com
Reprogramming of a differentiated cell back to a naive pluripotent identity is thought to occur
by several independent mechanisms. Two such mechanisms include NANOG and activated�…
by several independent mechanisms. Two such mechanisms include NANOG and activated�…
Instructing na�ve pluripotency; JAK/STAT3 and Nanog in reprogramming
AL Van Oosten - 2013 - repository.cam.ac.uk
Reprogramming of somatic cells to pluripotency is a topic of extensive research driven by
the potential of induced pluripotent cells in in vitro disease modelling, drug screening and�…
the potential of induced pluripotent cells in in vitro disease modelling, drug screening and�…
[PDF][PDF] Supplemental Information Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions
TW Theunissen, AL van Oosten, G Castelo-Branco… - Citeseer
(A) Chimaeric mouse obtained after injecting 2i-iPS cells derived from NS-OKM pre-iPS
clone 1 in C57/BL6 blastocysts. Agouti coat color indicates chimaeric contribution (MF1/129�…
clone 1 in C57/BL6 blastocysts. Agouti coat color indicates chimaeric contribution (MF1/129�…
[PDF][PDF] Aliaksandra Radzisheuskaya, Graziano Martello, Anzy Miller, Sabine Dietmann, Jennifer Nichols, and Jos� CR Silva
HT Stuart, AL van Oosten�- Current Biology, 2014 - cyberleninka.org
Reprogramming of a differentiated cell back to a naive pluripotent identity is thought to occur
by several independent mechanisms. Two such mechanisms include NANOG and activated�…
by several independent mechanisms. Two such mechanisms include NANOG and activated�…
[CITATION][C] Statistically stable models for determination of PEC
WJ Homan, AL Van Oosten - 1999 - IRG Secretariat