The advent of new technologies for the imaging of living cells has made it possible to
determine the properties of transcription, the kinetics of polymerase movement, the�…

We imaged transcription in living cells using a locus-specific reporter system, which allowed
precise, single-cell kinetic measurements of promoter binding, initiation and elongation�…

Live-cell single mRNA imaging is a powerful tool but has been restricted in higher
eukaryotes to artificial cell lines and reporter genes. We describe an approach that enables�…

Synthesis of mRNA in eukaryotes involves the coordinated action of many enzymatic
processes, including initiation, elongation, splicing, and cleavage. Kinetic competition�…

Patient-derived induced pluripotent stem cells (iPSCs) provide an opportunity to study
human diseases mainly in those cases for which no suitable model systems are available�…

Neural rosettes develop from the self-organization of differentiating human pluripotent stem
cells. This process mimics the emergence of the embryonic central nervous system�…

Microglia cells are active players in regulating synaptic development and plasticity in the
brain. However, how they influence the normal functioning of synapses is largely unknown�…

The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous
RNA-binding protein, and the mechanisms leading to selective motoneuron loss�…

Altered cellular biomechanics have been implicated as key photogenic triggers in age-
related diseases. An aberrant liquid-to-solid phase transition, observed in in vitro�…

Human ferritins have been extensively studied to be used as nanocarriers for diverse
applications and could represent a convenient alternative for targeted delivery of anticancer�…