Human genetics has been haunted by the mystery of “missing heritability” of common traits.
Although studies have discovered> 1,200 variants associated with common diseases and�…

There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been�…

Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported.
These RNAs are evolutionarily conserved in mammalian genomes and thus presumably�…

Genetic studies have revealed thousands of loci predisposing to hundreds of human
diseases and traits, revealing important biological pathways and defining novel therapeutic�…

Predicting at the time of discovery the prognosis and metastatic potential of cancer is a major
challenge in current clinical research. Numerous recent studies searched for gene�…

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance,. When MI occurs early in life, genetic inheritance is a major�…

The comparison of related genomes has emerged as a powerful lens for genome
interpretation. Here we report the sequencing and comparative analysis of 29 eutherian�…

The human genome contains hundreds of regions whose patterns of genetic variation
indicate recent positive natural selection, yet for most the underlying gene and the�…

Models of mammalian regulatory networks controlling gene expression have been inferred
from genomic data but have largely not been validated. We present an unbiased strategy to�…

During disease progression the cells that comprise solid malignancies undergo significant
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…