The large variability in mRNA and protein levels found from both static and dynamic
measurements in single cells has been largely attributed to random periods of transcription�…

Summary Purpose and Methods Trop-2 is a glycoprotein over-expressed in many solid
tumors but at low levels in normal human tissue, providing a potential therapeutic target. We�…

PF‐06647263, a novel antibody–drug conjugate consisting of an anti‐EFNA4 antibody
linked to a calicheamicin payload, has shown potent antitumor activity in human xenograft�…

The relationship between regulatory trans-factors binding a gene's cis-regulatory sequence
elements and the transcriptional output of that gene is fundamental to even the most�…

Background The effectiveness of many targeted therapies is limited by toxicity and the rise of
drug resistance. A growing appreciation of the inherent redundancies of cancer signaling�…

Fluorescence time-lapse microscopy has become a powerful tool in the study of many
biological processes at the single-cell level. In particular, movies depicting the temporal�…

Target-engagement pharmacodynamic (PD) biomarkers are valuable tools in the
prioritization of drug candidates, especially for novel, first-in-class mechanisms whose�…

A growing body of clinical evidence supports a view that the often observed refractory tumor
rebound arises from variation in treatment response among tumor subclones already�…

Short Abstract—The large variability in mRNA and protein levels found from single cell
measurements has been largely attributed to random periods of transcription, often�…

Growing evidence frames cancer as a disease of somatic Darwinian evolution. Recent
reports establish both inter-and intra-tumor genetic heterogeneity within patients, and�…