Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants
The number and diversity of known CRISPR–Cas systems have substantially increased in
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas�…
recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas�…
Copy number variation in human health, disease, and evolution
Copy number variation (CNV) is a source of genetic diversity in humans. Numerous CNVs
are being identified with various genome analysis platforms, including array comparative�…
are being identified with various genome analysis platforms, including array comparative�…
The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from�…
W Zhang, Y Zhao, F Zhang, Q Wang, T Li, Z Liu…�- Clinical�…, 2020 - Elsevier
The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all
over the world. Reports from China showed that about 20% of patients developed severe�…
over the world. Reports from China showed that about 20% of patients developed severe�…
[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent�…
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent�…
[PDF][PDF] Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
FU Yang, L Zhang, X Huo, J Yuan, D Xu, S Yuan…�- …, 2011 - Wiley Online Library
In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical
regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus�…
regulatory roles in cancer biology. However, the contributions of lncRNAs to hepatitis B virus�…
[HTML][HTML] Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
Targeted genome editing technologies have enabled a broad range of research and
medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted�…
medical applications. The Cas9 nuclease from the microbial CRISPR-Cas system is targeted�…
Comparative genomics reveals insights into avian genome evolution and adaptation
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance
across many research fields. We explored bird macroevolution using full genomes from 48�…
across many research fields. We explored bird macroevolution using full genomes from 48�…
Multiplex genome engineering using CRISPR/Cas systems
Functional elucidation of causal genetic variants and elements requires precise genome
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short�…
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short�…
[HTML][HTML] Event generator tunes obtained from underlying event and multiparton scattering measurements
V Khachatryan, AM Sirunyan, A Tumasyan…�- The European Physical�…, 2016 - Springer
New sets of parameters (“tunes”) for the underlying-event (UE) modelling of the pythia 8,
pythia6 and herwig++ Monte Carlo event generators are constructed using different parton�…
pythia6 and herwig++ Monte Carlo event generators are constructed using different parton�…
Enhanced nitrogen deposition over China
China is experiencing intense air pollution caused in large part by anthropogenic emissions
of reactive nitrogen,. These emissions result in the deposition of atmospheric nitrogen (N) in�…
of reactive nitrogen,. These emissions result in the deposition of atmospheric nitrogen (N) in�…