IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of
responsive genes. IFNs were the first human proteins to be effective in cancer therapy and�…

A change in chromosome number that is not the exact multiple of the haploid karyotype is
known as aneuploidy. This condition interferes with growth and development of an organism�…

Cardiac involvement in patients with sarcoidosis is being increasingly recognised and is
associated with poor prognosis. Although environmental and genetic factors have been�…

The stop-signal procedure was used to examine the development of inhibitory control. A
group of 275 participants, 6 to 81 years of age, performed a visual choice reaction time (go)�…

Double‐stranded RNA‐dependent protein kinase (PKR) has been implicated in interferon
(IFN) induction, antiviral response and tumor suppression. We have generated mice devoid�…

The induction of interferon (IFN) genes by viruses or double-stranded RNA (dsRNA)
requires the assembly of a complex set of transcription factors on responsive DNA elements�…

Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and
mental retardation in humans and is a hallmark of cancer. We examined the effects of�…

To preserve genetic integrity, mammalian cells exposed to ionizing radiation activate the
ATM kinase, which initiates a complex response—including the S-phase checkpoint�…

A host of observations demonstrating the relationship between nuclear architecture and
processes such as gene expression have led to a number of new technologies for�…

Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that
cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer�…