The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in
extracellular matrix proteins, and in integrin receptors. A number of human diseases arise�…

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization�…

We report the sequence and analysis of the 814-megabase genome of the sea urchin
Strongylocentrotus purpuratus, a model for developmental and systems biology. The�…

Aneuploidy, an incorrect number of chromosomes, is the leading cause of miscarriages and
mental retardation in humans and is a hallmark of cancer. We examined the effects of�…

Despite the high prevalence and poor outcome of patients with metastatic lung cancer the
mechanisms of tumour progression and metastasis remain largely uncharacterized. Here we�…

Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this
condition is associated with a disease characterized by unabated proliferative potential�…

We isolated the full-length chicken IL-10 (chIL-10) cDNA from an expressed sequence tag
library derived from RNA from cecal tonsils of Eimeria tenella-infected chickens. It encodes a�…

Whole-chromosome copy number alterations, also known as aneuploidy, are associated
with adverse consequences in most cells and organisms. However, high frequencies of�…

Tumorigenesis is a multistep process that results from the sequential accumulation of
mutations in key oncogene and tumour suppressor pathways. Personalized cancer therapy�…

The tumor microenvironment modifies the malignancy of tumors. In solid tumors, this
environment is populated by many macrophages that, in genetic studies that depleted these�…