In mammalian genomes, the methylation of cytosine residues within CpG dinucleotides is
crucial to normal development and cell differentiation. However, methylation of cytosines in�…

BACKGROUND Colorectal cancer, for many years a prototypic model for the genetic basis of
cancer, is now increasingly cited as an exemplar of the role of epigenetic changes in�…

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome
characterised by a predisposition to early onset colorectal, endometrial and other cancers�…

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory
autocrine and paracrine signals, involving overexpression of secreted peptide growth�…

An unpassaged, safety-tested strain (CJN) of human rotavirus from a stool specimen of a
hospitalized child was administered orally to 62 adult volunteers for determination of the�…

The Laser Interferometer Gravitational Wave Observatory (LIGO) has been directly detecting
gravitational waves from compact binary mergers since 2015. We report on the first use of�…

Epigenetic silencing can mimic genetic mutation by abolishing expression of a gene. We
hypothesized that an epimutation could occur in any gene as a germline event that�…

Abstract Purpose: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the
tumor growth factor β (TGF-β) superfamily. Several observations suggest that it plays a role�…

Activation of the canonical TGF-β signaling pathway provides growth inhibitory signals in the
normal intestinal epithelium. Colorectal cancers (CRCs) frequently harbor somatic mutations�…

Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the
body (a germ-line epimutation) have a predisposition for the development of cancer in a�…