Over the past decade, comprehensive sequencing efforts have revealed the genomic
landscapes of common forms of human cancer. For most cancer types, this landscape�…

Tumorigenesis has long been thought to be a multistep process (Foulds, 1958); however,
only recently has it become possible to identify the molecular events that underlie the�…

Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the�…

It has been suggested that cancer represents an alteration in DNA, heritable by progeny
cells, that leads to abnormally regulated expression of normal cellular genes; DNA�…

Because most colorectal carcinomas appear to arise from adenomas, studies of different
stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor�…

Some tissue types give rise to human cancers millions of times more often than other tissue
types. Although this has been recognized for more than a century, it has never been�…

The ability of~ 53 to activate transcription from specific sequences suggests that genes
induced by p53 may mediate its biological role as a tumor suppressor. Using a subtractive�…

Human cancer is caused by the accumulation of mutations in oncogenes and tumor
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we�…

More than 2% of the adult US population harbors a pancreatic cyst. These often pose a
difficult management problem because conventional criteria cannot always distinguish cysts�…

Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in
which they originated,, is the most common cause of death in cancer patients. This is�…