Individual cells in genetically homogeneous populations have been found to express
different numbers of molecules of specific proteins. We investigated the origins of these�…

Introns are removed from pre-mRNAs during transcription while the pre-mRNA is still
tethered to the gene locus via RNA polymerase. However, during alternative splicing, it is�…

The mechanism of transport of mRNA-protein (mRNP) complexes from transcription sites to
nuclear pores has been the subject of many studies. Using molecular beacons to track�…

When oligonucleotide probes are microinjected into cells to image the distribution of RNAs,
they are rapidly sequestered into the nucleus. As a result, it is difficult to detect mRNAs in the�…

We describe the use of “SuperSelective” primers that enable the detection and quantitation
of somatic mutations whose presence relates to cancer diagnosis, prognosis, and therapy, in�…

In PCR assays designed to detect rare somatic mutations, SuperSelective primers, by virtue
of their short 3′-foot sequences, selectively initiate synthesis on mutant DNA target�…

SuperSelective primers, by virtue of their unique design, enable the selective exponential
amplification of rare DNA fragments containing somatic mutations in the presence of�…

SuperSelective primers, by virtue of their unique design, enable the simultaneous
identification and quantitation of inherited reference genes and rare somatic mutations in�…

Here, we describe a stochastic model of gene expression which explains the mRNA bursts
observed in the experiments detailed in the main text. We analyze a model of gene�…

Work and the activities and technologies that allow any work to be performed seem to be
given issues in contemporary modern market-capitalist economies. However such issues�…