Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk
neuroblastoma is< 50%. While most high-risk neuroblastoma patients initially respond to�…

A major challenge to personalized oncology is that driver mutations vary among cancer cells
inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian�…

Understanding the complete immune cell composition of human neuroblastoma (NB) is
crucial for the development of immunotherapeutics. Here, we perform single-cell RNA�…

Genetic differences among neoplastic cells within the same tumour have been proposed to
drive cancer progression and treatment failure. Whether data on intratumoral diversity can�…

Clear cell sarcoma of the kidney (CCSK) is a rare tumor type affecting infants and young
children. Most CCSKs display few genomic aberrations, and no general underlying�…

Darwinian evolution of tumor cells remains underexplored in childhood cancer. We here
reconstruct the evolutionary histories of 56 pediatric primary tumors, including 24�…

Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor.
Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE�…

An unbalanced chromosome number (aneuploidy) is present in most malignant tumours and
has been attributed to mitotic mis-segregation of chromosomes. However, recent studies�…

Constitutional aneuploidy is typically caused by a single-event meiotic or early mitotic error.
In contrast, somatic aneuploidy, found mainly in neoplastic tissue, is attributed to continuous�…

Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of
patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent�…