The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a
steady, predictable decline in lung function over time. Recent evidence suggests that some�…

Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the�…

Cytokines are signal molecules that induce movement, differentiation, growth and death of
many cell types. Cytokines generate these effects through interactions with receptors, which�…

Although culture-independent techniques have shown that the lungs are not sterile, little is
known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We�…

Langerhans cells (LC) have recently been shown to be the only epidermal cells that bear Fc
and C3 receptors, and that express Ia antigens on their surface, supporting the hypothesis�…

Objective.—To evaluate the efficacy and safety of anti—tumor necrosis factor α monoclonal
antibody (TNF-α MAb) in the treatment of patients with sepsis syndrome. Design�…

Pulmonary fibrosis can be modeled in animals by intratracheal instillation of FITC, which
results in acute lung injury, inflammation, and extracellular matrix deposition. We have�…

Cellular constituents of the alveolar-capillary wall may be key participants in the recruitment
of polymorphonuclear leukocytes to the lung through the generation of the novel neutrophil�…

Findings of surgical lung biopsy (SLB) are important in categorizing patients with idiopathic
interstitial pneumonia (IIP). We investigated whether histologic variability would be evident�…

Current guidelines recommend that the clinician, radiologist, and pathologist work together
to establish a diagnosis of idiopathic interstitial pneumonia. Three clinicians, two�…