Deciphering the mechanisms of epigenetic reprogramming provides fundamental insights
into cell fate decisions, which in turn reveal strategies to make the reprogramming process�…

Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier," naive" state of pluripotency may�…

Recent studies have aimed to convert cultured human pluripotent cells to a naive state, but it
remains unclear to what extent the resulting cells recapitulate in vivo naive pluripotency�…

Pluripotent stem cells have broad utility in biomedical research and their molecular
regulation has thus garnered substantial interest. While the principles that establish and�…

Induced pluripotent stem (iPS) cells are generated from somatic cells by genetic
manipulation. Reprogramming entails multiple transgene integrations and occurs apparently�…

Embryonic stem (ES) cells are pluripotent, and of therapeutic potential in regenerative
medicine,. Understanding pluripotency at the molecular level should illuminate fundamental�…

Pluripotency is generated naturally during mammalian development through formation of the
epiblast, founder tissue of the embryo proper. Pluripotency can be recreated by somatic cell�…

Technologies allowing for specific regulation of endogenous genes are valuable for the
study of gene functions and have great potential in therapeutics. We created the CRISPR-on�…

Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre�…

The past decade has seen significant interest in the isolation of pluripotent stem cells
corresponding to various stages of mammalian embryonic development. Two distinct and�…