In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture�…

The correlation between cell shape elongation and the orientation of the division axis
described by early cell biologists is still used as a paradigm in developmental studies�…

The original micropatterning technique on gold, although very efficient, is not accessible to
most biology labs and is not compatible with their techniques for image acquisition. Other�…

Control of the establishment of cell polarity is an essential function in tissue morphogenesis
and renewal that depends on spatial cues provided by the extracellular environment. The�…

The cell division axis determines the future positions of daughter cells and is therefore
critical for cell fate. The positioning of the division axis has been mostly studied in systems�…

The architecture and adhesiveness of a cell microenvironment is a critical factor for the
regulation of spindle orientation in vivo,. Using a combination of theory and experiments, we�…

The organization of cells into epithelium depends on cell interaction with both the
extracellular matrix (ECM) and adjacent cells. The role of cell–cell adhesion in the regulation�…

Cells display a large variety of shapes when plated in classical culture conditions despite
their belonging to a common cell type. These shapes are transitory, since cells permanently�…

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly�…

Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead
to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because�…