An RNA hairpin is an essential secondary structure of RNA. It can guide RNA folding,
determine interactions in a ribozyme, protect messenger RNA (mRNA) from degradation�…

RNA silencing is a complex of mechanisms that regulate gene expression through small
RNA molecules. The microRNA (miRNA) pathway is the most common of these in mammals�…

In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which�…

Specific mRNA degradation mediated by double-stranded RNA (dsRNA), which is termed
RNA interference (RNAi), is a useful tool with which to study gene function in several�…

Context The expression and release of tissue factor is a major trigger for the activation of
coagulation in patients with sepsis. Tissue factor pathway inhibitor (TFPI) forms a complex�…

In mammals, a single Dicer participates in biogenesis of small RNAs in microRNA (miRNA)
and RNAi pathways. In mice, endogenous RNAi is highly active in oocytes, but not in�…

Loss of microRNA (miRNA) pathway components negatively affects differentiation of
embryonic stem (ES) cells, but the underlying molecular mechanisms remain poorly defined�…

The extensive world-wide morbidity and mortality caused by influenza A viruses highlights
the need for new insights into the host immune response and novel treatment approaches�…

Both murine endogenous retrovirus-L (MuERV-L) and intracisternal A particle (IAP), two
autonomous long terminal repeat (LTR) retrotransposons, are activated during genome�…

The mammalian target of rapamycin (mTOR) is a key component of a signaling pathway
which integrates inputs from nutrients and growth factors to regulate cell growth. Recent�…