Spindle poisons, such as paclitaxel and vinblastine, exert their potent anti-neoplastic effects
through activation of the spindle assembly checkpoint (SAC), thereby arresting cells in�…

Protein kinases are coded by more than 2,000 genes and thus constitute the largest single
enzyme family in the human genome. Most cellular processes are in fact regulated by the�…

Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase) that is distinct
from members of two other families of conventional PPIases, cyclophilins and FKBPs (FK�…

The stability of c-Myc is regulated by multiple Ras effector pathways. Phosphorylation at Ser
62 stabilizes c-Myc, whereas subsequent phosphorylation at Thr 58 is required for its�…

The Ndc80 complex lies at the heart of the kinetochore, a large protein machine that
accurately segregates chromosomes during cell division. The Ndc80 complex has structural�…

The separation of sister chromatids in anaphase depends on the dissociation of cohesin
from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the�…

Background: Sister kinetochores must bind microtubules in a bipolar fashion to equally
segregate chromosomes during mitosis. The molecular mechanisms underlying this process�…

Aurora B is a component of the chromosomal passenger complex (CPC) required for correct
spindle-kinetochore attachments during chromosome segregation and for cytokinesis. The�…

DNA polymerase III holoenzyme (holoenzyme), the multiprotein replicase of Escherichia
coli, is essentially unlimited in processive DNA synthesis. Processive activity can be�…

Aurora family serine/threonine kinases control mitotic progression, and their deregulation is
implicated in tumorigenesis. Aurora A and Aurora B, the best-characterized members of�…