Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of
polyploid cells are not well understood. During evolution, polyploidy is thought to be an�…

Aneuploidy is one of the most obvious differences between normal and cancer cells.
However, there remains debate over how aneuploid cells arise and whether or not they are�…

Polyploidy, an increased number of chromosome sets, is a surprisingly common
phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in�…

Polyploidy, increased sets of chromosomes, occurs during development, cellular stress,
disease and evolution. Despite its prevalence, little is known about the physiological�…

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe
developmental defects, yet the molecular mechanisms explaining its effects on cellular�…

Extra chromosome copies markedly alter the physiology of eukaryotic cells, but the
underlying reasons are not well understood. We created human trisomic and tetrasomic cell�…

Ploidy changes are frequent in nature and contribute to evolution, functional specialization
and tumorigenesis. Analysis of model organisms of different ploidies revealed that increased�…

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment. However,
it is unclear whether aneuploidy generates any clinically relevant vulnerabilities in cancer�…

Do young and old protein molecules have the same probability to be degraded? We
addressed this question using metabolic pulse-chase labeling and quantitative mass�…

Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to�…