Molecular portraits of breast cancer: tumour subtypes as distinct disease entities -
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The 2012 IMPAKT task force investigated the medical usefulness of current methods for the
classification of breast cancer into the 'intrinsic'molecular subtypes (luminal A, luminal B�…

Characteristic patterns of gene expression measured by DNA microarrays have been used
to classify tumors into clinically relevant subgroups. In this study, we have refined the�…

The purpose of this study was to classify breast carcinomas based on variations in gene
expression patterns derived from cDNA microarrays and to correlate tumor characteristics to�…

Triple-negative breast cancers (TNBC), characterized by absence of estrogen receptor (ER),
progesterone receptor (PR) and lack of overexpression of human epidermal growth factor�…

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity�…

A data base is described in which over 2,500 mutations in the p53 gene of human tumors
and tumor cell lines are compiled from a systematic search of reports published before 1�…

Based on the hypothesis that features of the molecular program of normal wound healing
might play an important role in cancer metastasis, we previously identified consistent�…

Genomic DNA copy number alterations are key genetic events in the development and
progression of human cancers. Here we report a genome-wide microarray comparative�…

Background Gene expression profiling has been used to define molecular phenotypes of
complex diseases such as breast cancer. The luminal A and basal-like subtypes have been�…