Microsystems create new opportunities for the spatial and temporal control of cell growth
and stimuli by combining surfaces that mimic complex biochemistries and geometries of the�…

Cell death plays an essential role in the development of tissues and organisms, the etiology
of disease, and the responses of cells to therapeutic drugs. Here we review progress made�…

Combination therapies are superior to monotherapy for many cancers. This advantage was
historically ascribed to the ability of combinations to address tumor heterogeneity, but�…

In microorganisms, noise in gene expression gives rise to cell-to-cell variability in protein
concentrations,,,,,,. In mammalian cells, protein levels also vary,, and individual cells differ�…

Drug sensitivity and resistance are conventionally quantified by IC50 or E max values, but
these metrics are highly sensitive to the number of divisions taking place over the course of�…

Combination cancer therapies aim to improve the probability and magnitude of therapeutic
responses and reduce the likelihood of acquired resistance in an individual patient�…

Heat shock promoters contain one or more binding sites for a specific heat shock factor
(HSF). We report the cloning and sequence of the gene encoding yeast HSF, and�…

Single-cell analysis reveals aspects of cellular physiology not evident from population-
based studies, particularly in the case of highly multiplexed methods such as mass�…

The architecture of normal and diseased tissues strongly influences the development and
progression of disease as well as responsiveness and resistance to therapy. We describe a�…

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients�…