Understanding nuclear architecture is indispensable for understanding the cell-type-
dependent orchestration of active and silent genes and other nuclear functions, such as�…

Advances in the specific fluorescent labeling of chromatin in fixed and living human cells in
combination with three-dimensional (3D) and 4D (space plus time) fluorescence microscopy�…

Genome-wide molecular studies have provided new insights into the organization of nuclear
chromatin by revealing the presence of chromatin domains of differing transcriptional�…

We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in
nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional�…

Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in�…

The three-dimensional organization of chromosomes within the nucleus and its dynamics
during differentiation are largely unknown. To visualize this process in molecular detail, we�…

Studies of higher-order chromatin arrangements are an essential part of ongoing attempts to
explore changes in epigenome structure and their functional implications during�…

The nucleus of mammalian cells displays a distinct spatial segregation of active euchromatic
and inactive heterochromatic regions of the genome,. In conventional nuclei, microscopy�…

The nuclear lamins function in the regulation of replication, transcription, and epigenetic
modifications of chromatin. However, the mechanisms responsible for these lamin functions�…

We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454
sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin�…