Reconstructing the lineage relationships and dynamic event histories of individual cells
within their native spatial context is a long-standing challenge in biology. Many biological�…

Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each
exhibiting stochastic noise in its gene expression. A major challenge is to disentangle these�…

Cellular reprogramming highlights the epigenetic plasticity of the somatic cell state. Long
noncoding RNAs (lncRNAs) have emerging roles in epigenetic regulation, but their potential�…

As they proliferate, living cells undergo transitions between specific molecularly and
developmentally distinct states. Despite the functional centrality of these transitions in�…

Synthetic biology is transforming therapeutic paradigms by engineering living cells and
microbes to intelligently sense and respond to diseases including inflammation, infections�…

While decades of research have elucidated many steps of the alphavirus lifecycle, the
earliest replication dynamics have remained unclear. This missing time window has�…

ABSTRACT ADP-ribosylation is a highly dynamic posttranslational modification frequently
studied in stress response pathways with recent attention given to its role in response to viral�…

The ability to extrapolate gene expression dynamics in living single cells requires robust cell
segmentation, and one of the challenges is the amorphous or irregularly shaped cell�…

The ability of bacteria and viruses to selectively replicate in tumors has led to synthetic
engineering of new microbial therapies. Here we design a cooperative strategy whereby S�…

Synthetic biology has led to advances in both our understanding and engineering of genetic
circuits that affect spatial and temporal behaviors in living cells. A growing array of native�…