[HTML][HTML] Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells
WT Silkworth, IK Nardi, LM Scholl, D Cimini�- PloS one, 2009 - journals.plos.org
Many cancer cells display a CIN (C hromosome In stability) phenotype, by which they exhibit
high rates of chromosome loss or gain at each cell cycle. Over the years, a number of�…
high rates of chromosome loss or gain at each cell cycle. Over the years, a number of�…
[HTML][HTML] Transient defects of mitotic spindle geometry and chromosome segregation errors
WT Silkworth, D Cimini�- Cell division, 2012 - Springer
Assembly of a bipolar mitotic spindle is essential to ensure accurate chromosome
segregation and prevent aneuploidy, and severe mitotic spindle defects are typically�…
segregation and prevent aneuploidy, and severe mitotic spindle defects are typically�…
Timing of centrosome separation is important for accurate chromosome segregation
WT Silkworth, IK Nardi, R Paul…�- Molecular biology of�…, 2012 - Am Soc Cell Biol
Spindle assembly, establishment of kinetochore attachment, and sister chromatid separation
must occur during mitosis in a highly coordinated fashion to ensure accurate chromosome�…
must occur during mitosis in a highly coordinated fashion to ensure accurate chromosome�…
[HTML][HTML] The mitotic origin of chromosomal instability
SF Bakhoum, WT Silkworth, IK Nardi, JM Nicholson…�- Current Biology, 2014 - cell.com
Chromosomal instability (CIN) is a common feature of most human neoplasms and was
defined, in a seminal study by Vogelstein and colleagues [1], as persistently elevated rates�…
defined, in a seminal study by Vogelstein and colleagues [1], as persistently elevated rates�…
Computer simulations predict that chromosome movements and rotations accelerate mitotic spindle assembly without compromising accuracy
The mitotic spindle self-assembles in prometaphase by a combination of centrosomal
pathway, in which dynamically unstable microtubules search in space until chromosomes�…
pathway, in which dynamically unstable microtubules search in space until chromosomes�…
[HTML][HTML] Changes in gene expression and cellular architecture in an ovarian cancer progression model
Background Ovarian cancer is the fifth leading cause of cancer deaths among women. Early
stage disease often remains undetected due the lack of symptoms and reliable biomarkers�…
stage disease often remains undetected due the lack of symptoms and reliable biomarkers�…
[HTML][HTML] Chromosome bridges maintain kinetochore-microtubule attachment throughout mitosis and rarely break during anaphase
J Pampalona, E Roscioli, WT Silkworth, B Bowden…�- PloS one, 2016 - journals.plos.org
Accurate chromosome segregation during cell division is essential to maintain genome
stability, and chromosome segregation errors are causally linked to genetic disorders and�…
stability, and chromosome segregation errors are causally linked to genetic disorders and�…
The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation
WT Silkworth, KL Kunes, GC Nickel…�- Molecular biology of�…, 2018 - Am Soc Cell Biol
The formin Delphilin binds the glutamate receptor, GluRδ2, in dendritic spines of Purkinje
cells. Both proteins play a role in learning. To understand how Delphilin functions in�…
cells. Both proteins play a role in learning. To understand how Delphilin functions in�…
Cytotoxicity of nanostructured vanadium oxide on human cells in vitro
LS Rhoads, WT Silkworth, ML Roppolo…�- Toxicology in Vitro, 2010 - Elsevier
Vanadium oxide nanostructures have potential uses for electrochemistry and catalysis, yet
little is known about their toxicology. In this study, cultured human colon carcinoma cells�…
little is known about their toxicology. In this study, cultured human colon carcinoma cells�…
The effect of spindle geometry on the establishment of merotelic kinetochore attachment and chromosome mis-segregation
WT Silkworth - 2012 - vtechworks.lib.vt.edu
At any given time there are on the order of one hundred million cells undergoing mitosis in
the human body. To accurately segregate chromosomes, the cell forms the bipolar mitotic�…
the human body. To accurately segregate chromosomes, the cell forms the bipolar mitotic�…