Immune checkpoint inhibitors (ICIs) have improved overall survival for cancer patients,
however, optimal duration of ICI therapy has yet to be defined. Given ICIs were first used to�…

During disease progression the cells that comprise solid malignancies undergo significant
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most�…

Complex biological, technological, and sociological networks can be of very different sizes
and connectivities, making it difficult to compare their structures. Here we present an�…

We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor
sample on the basis of expression data. This score is determined, in a context-specific�…

Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence
to growth and proliferation. Here we show that naive CD4+ T cell activation induces a�…

To systematically define molecular features in human tumor cells that determine their degree
of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell�…

Background Responses to conventional donor lymphocyte infusion for postallogeneic
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell�…

L1-CAM, a neuronal cell adhesion receptor, is also expressed in a variety of cancer cells.
Recent studies identified L1-CAM as a target gene of β-catenin-T-cell factor (TCF) signaling�…

This was an extension of research by the same authors (2010) that investigated sports
reporters' perception of their use of Twitter as part of their professional journalistic duties�…