Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA�…

Simple Summary The gene encoding for the epigenetic regulator ATRX is gaining a
prominent position among the most important oncosuppressive genes of the human�…

One of the hallmarks of cancer consists in the ability of tumor cells to divide indefinitely, and
to maintain stable telomere lengths throughout the activation of specific telomere�…

One main function of telomeres is to maintain chromosome and genome stability. The rate of
telomere shortening can be accelerated significantly by chemical and physical�…

Background Telomeres are potential markers of mitotic cellular age and are associated with
physical ageing process. Long-term endurance training and higher aerobic exercise�…

Oxidative DNA damage, particularly 8-oxoguanine, represents the most frequent DNA
damage in human cells, especially at the telomeric level. The presence of oxidative lesions�…

DNA‐PKcs is the catalytic subunit of the DNA‐dependent protein kinase (DNA‐PK) complex
that functions in the non‐homologous end‐joining of double‐strand breaks, and it has been�…

Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is
precisely controlled to guarantee efficient compaction of the genome and proper�…

In recent years, terahertz (THz) radiation has been widely used in a variety of applications:
medical, security, telecommunications and military areas. However, few data are available�…

Telomeres are nucleoprotein structures at eukaryotic chromosome termini. Their stability is
preserved by a six-protein complex named shelterin. Among these, TRF1 binds telomere�…