Polyploidy can drive rapid adaptation in yeast
Polyploidy is observed across the tree of life, yet its influence on evolution remains
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to�…
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to�…
[HTML][HTML] Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
AM Selmecki, K Dulmage, LE Cowen…�- PLoS�…, 2009 - journals.plos.org
The evolution of drug resistance is an important process that affects clinical outcomes.
Resistance to fluconazole, the most widely used antifungal, is often associated with acquired�…
Resistance to fluconazole, the most widely used antifungal, is often associated with acquired�…
The influence of polyploidy on the evolution of yeast grown in a sub-optimal carbon source
AL Scott, PA Richmond, RD Dowell…�- Molecular biology and�…, 2017 - academic.oup.com
Polyploidization events have occurred during the evolution of many fungi, plant, and animal
species and are thought to contribute to speciation and tumorigenesis, however little is�…
species and are thought to contribute to speciation and tumorigenesis, however little is�…
[HTML][HTML] antifungal pipeline: build it strong; build it better!
JR Perfect, DJ Krysan, M Del Poeta…�- Frontiers in cellular�…, 2022 - frontiersin.org
The global burden of fungal infections remains unclear but there are estimates that they
infect over a billion people with 150 million having serious fungal diseases and invasive�…
infect over a billion people with 150 million having serious fungal diseases and invasive�…
[HTML][HTML] Low Dosage of Histone H4 Leads to Growth Defects and Morphological Changes in Candida albicans
Chromatin function depends on adequate histone stoichiometry. Alterations in histone
dosage affect transcription and chromosome segregation, leading to growth defects and�…
dosage affect transcription and chromosome segregation, leading to growth defects and�…
Assembly of a complete genome sequence for Gemmata obscuriglobus reveals a novel prokaryotic rRNA operon gene architecture
Gemmata obscuriglobus is a Gram-negative bacterium with several intriguing biological
features. Here, we present a complete, de novo whole genome assembly for G�…
features. Here, we present a complete, de novo whole genome assembly for G�…
[PDF][PDF] Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of
AM Selmecki, K Dulmage, LE Cowen, JB Anderson… - 2009 - academia.edu
The evolution of drug resistance is an important process that affects clinical outcomes.
Resistance to fluconazole, the most widely used antifungal, is often associated with acquired�…
Resistance to fluconazole, the most widely used antifungal, is often associated with acquired�…
Chromosome loss rate in cells of different ploidy can be explained by spindle self-organization
I Jelenić, AM Selmecki, L Laan, N Pavin�- bioRxiv, 2017 - biorxiv.org
The mitotic spindle segregates chromosomes and minimizes chromosome loss for the
specific number of chromosomes present in an organism. In Saccharomyces cerevisiae, for�…
specific number of chromosomes present in an organism. In Saccharomyces cerevisiae, for�…
[CITATION][C] Aneuploidy and Drug Resistance in Candida Albicans
AM Selmecki - 2007 - University of Minnesota
[CITATION][C] Polyploidy can drive rapid adaptation in yeast. Nature 1–21
AM Selmecki, YE Maruvka, PA Richmond, M Guillet… - 2015 - Nature Publishing Group