Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in�…

Helicobacter pylori is a highly successful human‐specific gastric pathogen that colonizes
more than half the world's population. Infection with this bacterium can induce gastric�…

Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by
inducing degradation of target messenger RNAs. It is unknown how much translational�…

Several bacterial pathogens inject virulence proteins into host target cells that are substrates
of eukaryotic tyrosine kinases. One of the key examples is the Helicobacter pylori CagA�…

Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental�…

Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive�…

The gastric pathogen Helicobacter pylori uses a type IV secretion system to inject the
bacterial CagA protein into gastric epithelial cells. Within the host cell, CagA becomes�…

New antibiotics are urgently needed to control infectious diseases. Metabolic enzymes could
represent attractive targets for such antibiotics, but in vivo target validation is largely lacking�…

MaxQuant is a quantitative proteomics software package designed for analyzing large mass
spectrometric data sets. It is specifically aimed at high-resolution mass spectrometry (MS)�…

The gastric pathogen Helicobacter pylori translocates the CagA protein into epithelial cells
by a type IV secretion process. Translocated CagA is tyrosine phosphorylated (CagA P‐Tyr)�…