Promoter-proximal pausing by initiated RNA polymerase II (Pol II) and regulated release of
paused polymerase into productive elongation has emerged as a major mechanism of�…

The ability to evolve is a fundamental feature of biological systems, but the mechanisms
underlying this capacity and the evolutionary dynamics of conserved core processes remain�…

Aneuploidy—the state of having uneven numbers of chromosomes—is a hallmark of cancer
and a feature identified in yeast from diverse habitats,,,. Recent studies have shown that�…

Planarian flatworms regenerate every organ after amputation. Adult pluripotent stem cells
drive this ability, but how injury activates and directs stem cells into the appropriate lineages�…

Deafness caused by the terminal loss of inner ear hair cells is one of the most common
sensory diseases. However, nonmammalian animals (eg, birds, amphibians, and fish)�…

Aneuploid genomes, characterized by unbalanced chromosome stoichiometry (karyotype),
are associated with cancer malignancy and drug resistance of pathogenic fungi. The�…

Spatial control of gene expression, at the level of both transcription and translation, is critical
for cellular differentiation [1–4]. In budding yeast, the conserved Ndr/warts kinase Cbk1�…

Neoblasts are an abundant, heterogeneous population of adult stem cells (ASCs) that
facilitate the maintenance of planarian tissues and organs, providing a powerful system to�…

The interrelationship between endogenous microbiota, the immune system, and tissue
regeneration is an area of intense research due to its potential therapeutic applications. We�…

A large population of proliferative stem cells (neoblasts) is required for physiological tissue
homeostasis and post-injury regeneration in planarians. Recent studies indicate that�…