Gene expression is a multistep process that involves the transcription, translation and
turnover of messenger RNAs and proteins. Although it is one of the most fundamental�…

Animal microRNAs (miRNAs) regulate gene expression by inhibiting translation and/or by
inducing degradation of target messenger RNAs. It is unknown how much translational�…

Current methods for system‐wide gene expression analysis detect changes in mRNA
abundance, but neglect regulation at the level of translation. Pulse labeling with stable�…

Mark Biggin of the Lawrence Berkeley National Laboratory contacted us, noting that our
mass-spectrometry-based protein copy number estimates are lower than several literature�…

Protein-RNA interactions are fundamental to core biological processes, such as mRNA
splicing, localization, degradation, and translation. We developed a photoreactive�…

Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but
the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA�…

It is of fundamental importance to understand how the individual processes of gene
expression, transcription, and translation, as well as mRNA and protein stability, act in�…

We studied the dynamics of the proteome of influenza virus A/PR/8/34 (H1N1) infected
Madin-Darby canine kidney cells up to 12 hours post infection by mass spectrometry based�…

Purpose To evaluate whether 18 F-fluoroethyltyrosine (FET) PET can discriminate
progression from pseudoprogression of brain metastases in patients with non–small cell�…

Salmonella can cause a typhoid fever like disease in genetically susceptible mice. In
contrast to in vitro cell culture models, most host cells in infected tissues contain only one or�…