Technology in microscopy advances rapidly, enabling increasingly affordable, faster, and
more precise quantitative biomedical imaging, which necessitates correspondingly more�…

Fiji is a distribution of the popular open-source software ImageJ focused on biological-image
analysis. Fiji uses modern software engineering practices to combine powerful software�…

We present TrackMate, an open source Fiji plugin for the automated, semi-automated, and
manual tracking of single-particles. It offers a versatile and modular solution that works out of�…

Background ImageJ is an image analysis program extensively used in the biological
sciences and beyond. Due to its ease of use, recordable macro language, and extensible�…

We introduce a metric for probability distributions, which is bounded, information-
theoretically motivated, and has a natural Bayesian interpretation. The square root of the�…

State-of-the-art light and electron microscopes are capable of acquiring large image
datasets, but quantitatively evaluating the data often involves manually annotating structures�…

A key challenge in neuroscience is the expeditious reconstruction of neuronal circuits. For
model systems such as Drosophila and C. elegans, the limiting step is no longer the�…

Background Current imaging methods such as Magnetic Resonance Imaging (MRI),
Confocal microscopy, Electron Microscopy (EM) or Selective Plane Illumination Microscopy�…

To stimulate progress in automating the reconstruction of neural circuits, we organized the
first international challenge on 2D segmentation of electron microscopic (EM) images of the�…

The analysis highlighted an important role of chemokine signaling in colorectal cancer
progression and revealed previously undiscovered dynamic gene-expression patterns that�…