Embryo-derived stem cells can be considered archetypal stem cells. Among them,
embryonic stem cells (ESCs) are derived at an earlier stage of embryo development than�…

The Oct-4 POU transcription factor is expressed in mouse totipotent embryonic stem and
germ cells. Differentiation of totipotent cells to somatic lineages occurs at the blastocyst�…

The transcription factor Oct‐4 is expressed in totipotent embryonic cells and germ cells. As
totipotent cells differentiate to form somatic and/or extraembryonic tissues, the Oct‐4 gene is�…

Oct‐4 is a maternally expressed octamer‐binding protein encoded by the murine Oct‐4
gene. It is present in unfertilized oocytes, but also in the inner cell mass and in primordial�…

We have analysed various adult organs and different developmental stages of mouse
embryos for the presence of octamer‐binding proteins. A variety of new octamer‐binding�…

MEMBERS of a family of murine octamer-binding proteins inter-act specifically with the
octamer motif, a transcription regulatory element found in the promoter and enhancer�…

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins: Cell Stem Cell Skip
to Main Content Advertisement Cell Stem Cell This journal offers authors two options (open�…

Continuation of mammalian species requires the formation and development of the sexually
dimorphic germ cells. Cultured embryonic stem cells are generally considered pluripotent�…

The four transcription factors Oct4, Sox2, Klf4, and c-Myc can induce pluripotency in mouse
and human fibroblasts. We previously described direct reprogramming of adult mouse�…

Oct-4 is the earliest expressed gene known to encode a transcription factor which is
developmentally regulated during mammalian embryogenesis. In order to understand the�…