More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have�…

The main objective of this review was to assess the role of dairy cattle and their products in
human infections with Shiga toxin-producing Escherichia coli (STEC). A large number of�…

We describe a group of alloys that exhibit “super” properties, such as ultralow elastic
modulus, ultrahigh strength, super elasticity, and super plasticity, at room temperature and�…

Study Design. Consecutive case series and literature review. Objective. To describe the
utility of 3-dimensional computed tomographic angiography (3D CTA) for evaluating�…

Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease,
which can be freely designed and easily constructed. Numerous methods of constructing�…

Programmable nucleases enable engineering of the genome by utilizing endogenous DNA
double-strand break (DSB) repair pathways. Although homologous recombination (HR)�…

The structure and function of chromatin can be altered by modifications to histone. Histone
acetylation is a reversible process governed by histone acetyltransferases and histone�…

CRISPR/Cas9-mediated genome editing is a next-generation strategy for genetic
modifications, not only for single gene targeting, but also for multiple targeted mutagenesis�…

Genome engineering using programmable nucleases enables homologous recombination
(HR)-mediated gene knock-in. However, the labour used to construct targeting vectors�…

Transcription activator–like effector nucleases (TALENs) have recently arisen as effective
tools for targeted genome engineering. Here, we report streamlined methods for the�…