Epilepsy in elderly patients, compared with the younger adult population, differs in etiology,
clinical presentation, and prognosis. Challenges in the pharmacologic treatment of epilepsy�…

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples�…

Although APC mutations occur at a high frequency in colorectal cancers, few studies have
performed a comprehensive analysis by screening the whole gene for mutations and�…

Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is
known about their etiology and pathogenesis 1, 2, 3. We previously mapped a gene that�…

Background and Methods Although generalized convulsive status epilepticus is a life-
threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year�…

Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We
applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and�…

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the�…

Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal�…

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most�…

Objective: To determine the relative tolerability and efficacy of two newer antiepileptic drugs,
lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine (CBZ) in older�…