Improvements in genomic and molecular methods are expanding the range of potential
applications for circulating tumour DNA (ctDNA), both in a research setting and as a'liquid�…

A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection�…

MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that is involved in
oncogenesis and shows remarkable tissue specificity. Their potential for tumor classification�…

The quantitative relation between transcription factor concentrations and the rate of protein
production from downstream genes is central to the function of genetic networks. Here we�…

Cancers acquire resistance to systemic treatment as a result of clonal evolution and
selection,. Repeat biopsies to study genomic evolution as a result of therapy are difficult�…

Plasma of cancer patients contains cell-free tumor DNA that carries information on tumor
mutations and tumor burden. Individual mutations have been probed using allele-specific�…

Summary p53 is a potent tumor suppressor, whose biological effects are largely due to its
function as a transcriptional regulator. Here we report that, in addition to regulating the�…

Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on
genomic alterations but have rarely considered the biological properties of plasma cell-free�…

Background The management of metastatic breast cancer requires monitoring of the tumor
burden to determine the response to treatment, and improved biomarkers are needed�…

Cells regulate gene expression using networks of transcription interactions; it is of interest to
discover the principles that govern the dynamical behavior of such networks. An important�…