Purpose Complete resection constitutes the only curative approach in pancreatic cancer but
is possible only in a minority of patients due to advanced stages upon diagnosis�…

Background Colorectal cancer (CRC) is the second leading cause of cancer deaths despite
the fact that detection of this cancer in early stages results in over 90% survival rate�…

Background & Aims: A variety of gastrointestinal motility disorders have been attributed to
alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This�…

Background: Radical lymphadenectomy for colorectal cancer according to its arterial supply
seems to remove potentially me-tastatic lymph nodes and highlights the impact on�…

PURPOSE: Several alterations of the enteric nervous system have been described as an
underlying neuropathologic correlate in patients with idiopathic slow-transit constipation. To�…

Recently, expression profiling of breast carcinomas has revealed gene signatures that
predict clinical outcome, and discerned prognostically relevant breast cancer subtypes�…

Background The pathogenesis of diverticular disease (DD) is attributed to several
aetiological factors (eg age, diet, connective tissue disorders) but also includes distinct�…

Background & Aims: Late diagnosis of colorectal carcinoma results in a significant reduction
of average survival times. Yet despite screening programs, about 70% of tumors are�…

To identify sequential alterations of the genome, transcriptome, and proteome during
colorectal cancer progression, we have analyzed tissue samples from 36 patients, including�…

Abstract Changes in the proteome of colon mucosal cells accompany the transition from
normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15�…