The endoplasmic reticulum (ER) consists of tubules that are shaped by the reticulons and
DP1/Yop1p, but how the tubules form an interconnected network is unknown. Here, we�…

The hereditary spastic paraplegias (SPG1-33) comprise a cluster of inherited neurological
disorders characterized principally by lower extremity spasticity and weakness due to a�…

The e ndosomal s orting c omplex r equired for t ransport (ESCRT) machinery, including
ESCRT-III, localizes to the midbody and participates in the membrane-abscission step of�…

Mitochondrial morphology within cells is controlled by precisely regulated rates of fusion and
fission [1–4]. During programmed cell death (PCD), mitochondria undergo extensive�…

METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first�…

Background Anhedonia, the diminished ability to experience pleasure, is an important
dimensional entity linked to depression, schizophrenia, and other emotional disorders, but�…

Early-life adversity increases the risk for emotional disorders such as depression and
schizophrenia. Anhedonia, thought to be a core feature of these disorders, is provoked by�…

Recent literature suggests that bone marrow stromal cells (BMSCs) may be differentiated
into neuron-like and/or glia-like cells, implying that differentiated BMSCs may have potential�…

Objective To evaluate factors during acute presumed childhood encephalitis that are
associated with development of long-term neurological sequelae. Methods A total of 217�…

In a subset of children experiencing prolonged febrile seizures (FSs), the most common type
of childhood seizures, cognitive outcomes are compromised. However, the underlying�…