The transition of normal epithelium to invasive carcinoma occurs sequentially. In colorectal
and cervical carcinogenesis, this transition is reflected by histomorphologically defined�…

Chromosome 'painting'refers to the hybridization of fluorescently labeled chromosome-
specific, composite probe pools to cytological preparations. Chromosome painting allows�…

The simultaneous and unequivocal discernment of all human chromosomes in different
colors would be of significant clinical and biologic importance. Whole-genome scanning by�…

Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic�…

Comparative genomic hybridization was used to screen the DNA extracted from
histologically defined tissue sections from consecutive stages of colorectal carcinogenesis�…

The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces
cerevisiae,. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened�…

A murine model of ataxia telangiectasia was created by disrupting the Atm locus via gene
targeting. Mice homozygous for the disrupted Atm allele displayed growth retardation�…

Dysregulation of oncogenes by translocation to an IgH (14q32) or IgL (κ, 2p11 or λ, 22q11)
locus is a frequent event in the pathogenesis of B-cell tumors. Translocations involving an�…

We have developed an inducible system to visualize gene expression at the levels of DNA,
RNA and protein in living cells. The system is composed of a 200 copy transgene array�…

Germline mutations of the Brca1 tumor suppressor gene predispose women to breast and
ovarian cancers. To study mechanisms underlying BRCA1-related tumorigenesis, we�…