The many complex phenotypes of cancer have all been attributed to “somatic mutation.”
These phenotypes include anaplasia, autonomous growth, metastasis, abnormal cell�…

It has been difficult to find a common cause for the many and complex phenotypes of cancer
such as dedifferentiation, invasiveness, abnormal morphology, growth rate and metabolism�…

Proteases regulate a broad spectrum of physiological functions by the specific processing
ofproteins and peptides. Elevated levels of activeproteases can result in an array of�…

Genetic and phenotypic instability are hallmarks of cancer cells, but their cause is not clear.
The leading hypothesis suggests that a poorly defined gene mutation generates genetic�…

For nearly a century, cancer has been blamed on somatic mutation. But it is still unclear
whether this mutation is aneuploidy, an abnormal balance of chromosomes, or gene�…

The complexity and diversity of cancer-specific phenotypes, including de-differentiation,
invasiveness, metastasis, abnormal morphology and metabolism, genetic instability and�…

Almost two decades of unprecedented efforts in research costing US taxpayers over $50
billion have failed to defeat Acquired Immune Deficiency Syndrome (AIDS) and have failed�…

We evaluated the antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. A
number of vinyl sulfones strongly inhibited falcipain, a Plasmodium falciparum cysteine�…

We previously identified a Plasmodium falciparum trophozoite cysteine proteinase (TCP)
and hypothesized that it is required for the degradation of host hemoglobin by�…

Peptidyl vinyl sulphones are a novel class of extremely potent and specific cysteine protease
inhibitors. They are highly active against the therapeutically important cathepsins O2, S and�…