Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1β and-
18, which are important mediators of inflammation. Abnormal activation of the inflammasome�…

The SIR2 family of nicotinamide adenosine dinucleotide (NAD)-dependent deacetylases
modulates diverse biological functions in different species, including longevity, apoptosis�…

The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular
metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand�…

Cyclin D1 belongs to a family of proteins that regulate progression through the G1-S phase
of the cell cycle by binding to cyclin-dependent kinase (cdk)-4 to phosphorylate the�…

The activity of the p53 gene product is regulated by a plethora of posttranslational
modifications. An open question is whether such posttranslational changes act redundantly�…

microRNAs are thought to regulate tumor progression and invasion via direct interaction with
target genes within cells. Here the microRNA17/20 cluster is shown to govern cellular�…

The role of mammary epithelial cell (MEC) NF-κB in tumor progression in vivo is unknown,
as murine NF-κB components and kinases either are required for murine survival or interfere�…

The cyclin D1 gene encodes a regulatory subunit of the holoenzyme that phosphorylates
and inactivates the pRb tumor suppressor to promote nuclear DNA synthesis. cyclin D1 is�…

Cyclin D1 is overexpressed in human tumors, correlating with cellular metastasis, and is
induced by activating Rho GTPases. Herein, cyclin D1-deficient mouse embryo fibroblasts�…

By taking careful account of slab thickness and adsorbate orientation effects we present, for
the first time, periodic density functional calculations predicting the preference of water to�…