Transitions between epithelial and mesenchymal states have crucial roles in embryonic
development. Emerging data suggest a role for these processes in regulating cellular�…

Populations of tumour cells display remarkable variability in almost every discernable
phenotypic trait, including clinically important phenotypes such as ability to seed metastases�…

With rare exceptions, spontaneous tumors originate from a single cell. Yet, at the time of
clinical diagnosis, the majority of human tumors display startling heterogeneity in many�…

Human cancer is caused by the accumulation of mutations in oncogenes and tumor
suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we�…

The inactivation of the p53 gene in a large proportion of human cancers has inspired an
intense search for the encoded protein's physiological and biological properties. Expression�…

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island�…

Cells with distinct phenotypes including stem-cell-like properties have been proposed to
exist in normal human mammary epithelium and breast carcinomas, but their detailed�…

The epithelial-mesenchymal transition (EMT) is a key developmental program that is often
activated during cancer invasion and metastasis. We here report that the induction of an�…

Breast carcinoma is the leading cause of cancer-related mortality in women worldwide, with
an estimated 1.38 million new cases and 458,000 deaths in 2008 alone. This malignancy�…

Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in
G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase�…