There is persuasive clinical and experimental evidence that macrophages promote cancer
initiation and malignant progression. During tumor initiation, they create an inflammatory�…

Evidence from clinical and experimental studies indicates that macrophages promote solid-
tumour progression and metastasis. Macrophages are educated by the tumour�…

Specialized phagocytes are found in the most primitive multicellular organisms. Their roles
in homeostasis and in distinguishing self from non-self have evolved with the complexity of�…

In human breast carcinomas, overexpression of the macrophage colony–stimulating factor
(CSF-1) and its receptor (CSF-1R) correlates with poor prognosis. To establish if there is a�…

The development of a tumor vasculature or access to the host vasculature is a crucial step
for the survival and metastasis of malignant tumors. Although therapeutic strategies�…

Animal models are powerful tools to analyze the mechanism of the induction of human
breast cancer. Here we report a detailed analysis of mammary tumor progression in one�…

Macrophages, which are abundant in the tumour microenvironment, enhance malignancy.
At metastatic sites, a distinct population of metastasis-associated macrophages promotes�…

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue�…

Metastasis is a multistage process that requires cancer cells to escape from the primary
tumour, survive in the circulation, seed at distant sites and grow. Each of these processes�…

The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive�…