During disease progression the cells that comprise solid malignancies undergo significant
changes in gene copy number and chromosome structure. Colorectal cancer provides an�…

Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown�…

To provide a multi-omics resource and investigate transcriptional regulatory mechanisms,
we profile the transcriptome, chromatin accessibility, and methylation status of over 70,000�…

Despite their importance in tissue homeostasis and renewal, human pituitary stem cells
(PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and�…

Exercise has multi-systemic benefits and attenuates the physiological impairments
associated with aging. Emerging evidence suggests that circulating exosomes mediate�…

Control of gene expression following activation of membrane receptors results from the
regulation of intracellular signaling pathways and transcription factors. Accordingly, research�…

Mitochondria have diverse functions critical to whole-body metabolic homeostasis.
Endurance training alters mitochondrial activity, but systematic characterization of these�…

DNA methylation comprises a cumulative record of lifetime exposures superimposed on
genetically determined markers. Little is known about methylation dynamics in humans�…

The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating
1918 strain motivates finding strain-specific host–pathogen mechanisms. During infection�…

The ability to associate mutations in cancer genes with the disease and its subtypes is
critical for understanding oncogenesis and identifying biomarkers for clinical diagnosis. A�…