Rab GTPases are key proteins that determine organelle identity and operate at the center of
fusion reactions. Like Ras, they act as switches that are connected to a diverse network of�…

The dynamic equilibrium between vesicle fission and fusion at Golgi, endosome, and
vacuole/lysosome is critical for the maintenance of organelle identity. It depends, among�…

Extra chromosome copies markedly alter the physiology of eukaryotic cells, but the
underlying reasons are not well understood. We created human trisomic and tetrasomic cell�…

Correct chromosome segregation is essential in order to prevent aneuploidy. To segregate
sister chromatids equally to daughter cells, the sisters must attach to microtubules�…

Within the endomembrane system of eukaryotic cells, multisubunit tethering complexes
together with their corresponding Rab‐GTPases coordinate vesicle tethering and fusion�…

Polarization of macrophages is regulated through complex signaling networks. Correlating
miRNA and mRNA expression over time after macrophage polarization has not yet been�…

Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular
carcinoma (HCC), but little is known about the implications of heterogeneity and shared�…

Membrane tethering, the process of mediating the first contact between membranes
destined for fusion, requires specialized multisubunit protein complexes and Rab GTPases�…

Eggshell is the outermost calcified covering of an egg that protects it from microbial invasion
and physical damage, and is critical for egg quality. However, understanding of the�…

Background Racial/ethnic disparities in health reflect a combination of genetic and
environmental causes, and DNA methylation may be an important mediator. We compared�…