Caveolae are flask‐shaped invaginations present in the plasma membrane of many cell
types. They have long been implicated in endocytosis, transcytosis, and cell signaling�…

Single-cell measurements and lineage-tracing experiments are revealing that phenotypic
cell-to-cell variability is often the result of deterministic processes, despite the existence of�…

Viruses have long served as tools in molecular and cellular biology to study a variety of
complex cellular processes. Currently, there is a revived interest in virus entry into animal�…

Abstract Simian virus 40 (SV40) is unusual among animal viruses in that it enters cells
through caveolae, and the internalized virus accumulates in a smooth endoplasmic�…

Endocytosis is a key cellular process, encompassing different entry routes and endocytic
compartments. To what extent endocytosis is subjected to high-order regulation by the�…

Simian virus 40 (SV40) utilizes endocytosis through caveolae for infectious entry into host
cells. We found that after binding to caveolae, virus particles induced transient breakdown of�…

INTRODUCTION Obtaining multiplexed molecular readouts from large numbers of single
cells in situ is an important technological goal to facilitate scientific discoveries in basic and�…

Endocytosis comprises several routes of internalization. An outstanding question is whether
the caveolar and endosomal pathways intersect. Following transport of the caveolar protein�…

Single-cell heterogeneity in cell populations arises from a combination of intrinsic and
extrinsic factors,,. This heterogeneity has been measured for gene transcription�…

A functional genomics approach has revealed that caveolae/raft-mediated endocytosis is
subject to regulation by a large number of kinases. Here we explore the role of some of�…