Individual mammalian cells exhibit large variability in cellular volume, even with the same
absolute DNA content, and so must compensate for differences in DNA concentration in�…

Neuroblastoma is characterized by a relative paucity of recurrent somatic mutations at
diagnosis. However, recent studies have shown that the mutational burden increases at�…

Abstract Background Long non-coding RNAs (lncRNAs) have been implicated in diverse
biological processes. In contrast to extensive genomic annotation of lncRNA transcripts, far�…

With the advent of quantitative tools for measuring gene expression in single cells,
researchers have made the discovery that in many contexts, messenger RNA and protein�…

Degenerate networks, in which structurally distinct elements can perform the same function
or yield the same output, are ubiquitous in biology. Degeneracy contributes to the�…

Three-dimensional ordered lattices of nanoparticles (NPs) linked by DNA have potential
applications in novel devices and materials, but most experimental attempts to form crystals�…

To identify molecular mechanisms that function in G-protein signaling, we have performed
molecular genetic studies of a simple behavior of the nematode Caenorhabditis elegans�…

Human cells are dynamic: they grow, replicate their genetic information (DNA), and divide.
Clonal populations of cells can display marked heterogeneity in size, leading to significant�…

First, to Mrs. Sheryl Johnson, who initially inspired me to study physics. If it weren't for you,
this would probably be an English thesis. To my thesis advisor, Prof. Francis Starr, who�…

Peter Freddolino, Saeed Tavazoie. Columbia University, New York, NY, USA. The regulation
of gene expression plays a pivotal role in all aspects of biology, from the manner in which�…