Despite recent emerging evidence suggesting that cancer stem cells subsist in a variety of
tumors, it is not yet fully elucidated whether postnatal stem cells are directly involved in�…

Chromosomal instability (CIN) underlies malignant properties of many solid cancers and
their ability to escape therapy, and it might itself cause cancer [1, 2]. CIN is sustained by�…

Energy deregulation and abnormalities of tumor cell metabolism are critical issues in
understanding cancer. Hereditary leiomyomatosis renal cell carcinoma (HLRCC) is an�…

In cell and animal models, telomere erosion promotes chromosomal instability via breakage-
fusion-bridge cycles, contributing to the early stages of tumorigenesis. However, evidence�…

Classical banding methods provide basic information about the identities and structures of
chromosomes on the basis of their unique banding patterns. Spectral karyotyping (SKY)�…

In defining the genetic profiles in cancer, cytogenetically aberrant cell lines derived from
primary tumors are important tools for the study of carcinogenesis. Here, we present the�…

To evaluate the mechanisms and consequences of chromosomal aberrations in colorectal
cancer (CRC), we used a combination of spectral karyotyping, array comparative genomic�…

Jumping translocations (JTs) and segmental jumping translocations (SJTs) are unbalanced
translocations involving a donor chromosome arm or chromosome segment that has fused�…

Critically short telomeres activate p53-mediated apoptosis, resulting in organ failure and
leading to malignant transformation. Mutations in genes responsible for telomere�…

Epigenetic regulation of chromatin states is thought to control gene expression programs
during lineage specification. However, the roles of repressive histone modifications, such as�…