Microarrays first made the analysis of the transcriptome possible, and have produced much
important information. Today, however, researchers are increasingly turning to direct high�…

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The�…

Several contributing factors have been implicated in evolutionary rate heterogeneity among
proteins, but their evolutionary mechanisms remain poorly characterized. The recently�…

Comparative analysis of multiple genomes in a phylogenetic framework dramatically
improves the precision and sensitivity of evolutionary inference, producing more robust�…

Drosophila melanogaster is one of the most well studied genetic model organisms;
nonetheless, its genome still contains unannotated coding and non-coding genes�…

Accumulation of cholesterol causes both repression of genes controlling cholesterol
biosynthesis and cellular uptake and induction of cholesterol 7α-hydroxylase, which leads to�…

Steroid hormones exert profound effects on differentiation, development, and homeostasis in
higher eukaryotes through interactions with nuclear receptors. We describe a novel orphan�…

Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and cyclooxygenase
inhibitor that is frequently used as a research tool to study the process of adipocyte�…

To gain insight into how genomic information is translated into cellular and developmental
programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE)�…

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula�…