The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism,
survival and growth. Here, disruption of the ubiquitously expressed member of the Akt family�…

The role of mammary epithelial cell (MEC) NF-κB in tumor progression in vivo is unknown,
as murine NF-κB components and kinases either are required for murine survival or interfere�…

This is a study of the positions of the appendix in 548 Nigerians 447 of whom were
autopsies or cadavers while the rest (101) were appendicectomy patients. Overall, the�…

Peroxisome proliferator-activated receptor γ (PPARγ) is expressed in a variety of cancer
cells. The addition of ligand activates the receptor by inducing a conformational change in�…

The (HER2/Neu) ErbB2 oncogene is commonly overexpressed in human breast cancer and
is sufficient for mammary tumorigenesis in transgenic mice. Nuclear factor (NF)-κB activity is�…

Abstract GLIOBLASTOMA IS THE most malignant primary brain tumor. Inhibition of
angiogenesis is one potential strategy for treating this fatal hypervascular tumor. AGM-1470�…

By virtue of their location within blood vessels and their ability to express foreign genes,
endothelial cells are attractive vehicles for the delivery of therapeutic molecules in vivo. We�…

BACKGROUND Mouse prostate cancer modeling presents unique obstacles to the study of
spontaneous tumor initiation and progression due to the anatomical location of the tissue�…

Basal serum 17α-hydroxyprogesterone (17-OHP) concentrations and the 17-OHP response
to acute adrenocorticotropic hormone administration were studied in infertile men with�…

Cancer metastasis accounts for a significant proportion of morbidity and mortality in patients.
Effective means of treating disseminated disease remains elusive. The purpose of this study�…